. 2014 Feb 27;57(6):2237–2246. doi: 10.1021/jm400879w

Table 2. Opioid Receptor Binding Determined by Radioligand Displacement in Membrane Preparations with hMOR, hDOR, and hKOR Receptors Expressed in CHO Cells^45,46.

helix series	1 ∼B∼B∼	2 ∼A∼B∼	3 ∼B∼A∼	4 ∼A∼A∼	5 ∼A∼G∼	6 ∼G∼A∼	7 ∼G∼G∼	S°
μ-Binding (K_i’s in nM) vs [³H]DAMGO
L	21 ± 0.90	8.2 ± 0.60	13 ± 0.54	11 ± 1.4	9.6 ± 0.18	9.8 ± 0.97	5.0 ± 0.37	S**
G	9.1 ± 0.39	2.6 ± 0.29	6.1 ± 0.31	6.2 ± 0.47	2.2 ± 0.30	2.9 ± 0.32	3.5 ± 0.55	S*
U	29 ± 3.1	29 ± 0.67	21 ± 2.6	14 ± 2.3	13 ± 0.97	13 ± 1.2	12 ± 1.8	S
δ-Binding (K_i’s in nM) vs [³H]naltrindole
L	35 ± 3.0	12 ± 0.94	19 ± 0.67	12 ± 0.99	12 ± 1.0	8.2 ± 0.29	7.0 ± 0.57	S**
G	11 ± 1.2	3.6 ± 0.23	14 ± 2.1	7.9 ± 1.0	6.3 ± 0.094	5.7 ± 0.35	7.1 ± 1.0	S*
U	23 ± 2.8	15 ± 0.79	25 ± 1.6	16 ± 1.9	15 ± 0.98	11 ± 0.91	13 ± 2.2	S
κ-Binding (K_i’s in nM) vs [³H]U69,593
L	17 ± 1.9	5.7 ± 0.13	17 ± 1.6	15 ± 0.39	13 ± 0.76	23 ± 2.3	8.4 ± 1.2	S**
G	6.9 ± 0.58	2.3 ± 0.31	12 ± 0.94	8.9 ± 1.0	6.3 ± 0.41	11 ± 0.26	4.4 ± 0.47	S*
U	14 ± 1.4	16 ± 0.16	26 ± 1.6	14 ± 2.1	15 ± 1.3	20 ± 1.4	15 ± 1.9	S

Table 2. Opioid Receptor Binding Determined by Radioligand Displacement in Membrane Preparations with hMOR, hDOR, and hKOR Receptors Expressed in CHO Cells45,46.