. 2014 Jan 28;57(4):1557–1572. doi: 10.1021/jm401883v

Table 2. Stimulation of [³⁵S]GTPγS Binding to hD₂ and hD₃ Receptors Expressed in CHO Cells.

	CHO–D₂		CHO–D₃
compd	EC₅₀ (nM)^a [³⁵S]GTPγS	%E_max	EC₅₀ (nM)^a [³⁵S]GTPγS	%E_max	D₂/D₃
dopamine	218 ± 12	100	10.6 ± 2.1	100	26.5
1a^b	33.1 ± 6.6	104 ± 5	1.51 ± 0.02	90 ± 4.3	22.1
(−)-8b	36.8 ± 7.2	105 ± 6	3.42 ± 1.01	67.3 ± 5.6	10.8
(−)-9b	15.9 ± 1.8	116 ± 10	0.10 ± 0.02	95.8 ± 3.7	159

EC50 is the concentration producing half-maximal stimulation; for each compound, maximal stimulation (E_max) is expressed as percent of the E_max observed with 1 mM (D₂) or 100 uM (D₃) of the full agonist DA (%E_max). Results are the means ± SEM for 3–6 experiments each performed in triplicate.

From previous ref (43).

Table 2. Stimulation of [35S]GTPγS Binding to hD2 and hD3 Receptors Expressed in CHO Cells.

Table 2. Stimulation of [³⁵S]GTPγS Binding to hD₂ and hD₃ Receptors Expressed in CHO Cells.