Table 3. Pharmacokinetic Parameters of Equol Metabolites from a Single Oral Gavage of Dietary Equol Administered to Ovariectomized Rats (n = 5–6 Pairs)a.
| metabolite | HL (h) | tmax (h) | Cmax (nmol/L) | AUC0–24 (nmol/L·*h) | CL/F (L/h) | V/F (L) |
|---|---|---|---|---|---|---|
| total equol | 21.9 ± 8.02 | 2.17 ± 2.91 | 8815 ± 2988 | 104337 ± 20531 | 0.08 ± 0.03 | 2.32 ± 0.26 |
| unconjugated equol | 9.41 ± 3.93 | 4.42 ± 4.50 | 9.46 ± 3.56 | 96.0 ± 41.9 | 179 ± 138 | 1,937 ± 692 |
| equol monosulfate | 14.4 ± 9.26 | 3.20 ± 2.95 | 23.9 ± 8.54 | 234 ± 97 | 43.7 ± 11.7 | 912 ± 703 |
| equol glucuronides | 23.0 ± 2.91 | 2.17 ± 2.91 | 8775 ± 2976 | 104082 ± 20516 | 0.08 ± 0.03 | 2.38 ± 0.50 |
a
Values are means ± SD. Pharmacokinetic parameters: HL (elimination half-life), tmax (time of maximum concentration), Cmax (maximum concentration), AUC0–24 (area under plasma concentration time curve from 0 to 24 h), CL/F (clearance rate) = D/AUC0–24, V/F (volume of distribution)