Table 1.

Characteristics of Full Cohort and Validation Subgroup^a (n = 308), Multicenter Herpetic Eye Disease Study, 1992–1998

	Full Cohort (n = 308)		Validation Subgroup (n = 91)
	No. on Placebo	No. on Acyclovir	No. on Placebo	No. on Acyclovir
No self-reported recurrenceb
No diagnosed recurrence	104	119	30	35
Diagnosed recurrence	26	14	8	4
Self-reported recurrenceb
No diagnosed recurrence	11	10	3	3
Diagnosed recurrence	12	12	4	4
Sensitivityc	0.32	0.46	0.33	0.50
Specificityd	0.90	0.92	0.91	0.92

^a Self-reported outcomes and physician records were available for all 308 participants. We sampled a synthetic validation subgroup of 91 participants for the purposes of illustration.

^b Participants reported ocular HSV recurrences through a weekly diary and were seen by an ophthalmologist every 3 months. Self-reported recurrences were determined from data obtained from patient diaries, and physician-diagnosed recurrences were determined via examination by the study ophthalmologist.

^c Sensitivity was the proportion of patients with a physician-diagnosed recurrence who also self-reported a recurrence.

^d Specificity was the proportion of participants without a physician-diagnosed recurrence who did not self-report a recurrence.