Table 1.
The top 20 gene changes within the NFκB pathway observed in Huntington’s disease monocytes
| Gene name | Fold change | P-value |
|---|---|---|
| TLR2 | 1.483 | 0.010 |
| LTBR | 1.355 | 0.014 |
| CHUK | 0.771 | 0.015 |
| CD40 | 1.513 | 0.016 |
| TMED4 | 1.227 | 0.021 |
| AKT1 | 1.535 | 0.031 |
| IL10 | 1.850 | 0.037 |
| F2R | 2.232 | 0.041 |
| IRAK1 | 2.004 | 0.051 |
| JUN | 2.215 | 0.051 |
| TICAM2 | 1.319 | 0.051 |
| MYD88 | 1.262 | 0.053 |
| FOS | 1.867 | 0.059 |
| TRADD | 1.251 | 0.062 |
| RAF1 | 1.121 | 0.065 |
| SLC44A2 | 1.292 | 0.066 |
| ATF1 | 1.156 | 0.071 |
| IL6 | 2.486 | 0.075 |
| GJA1 | 0.612 | 0.080 |
| CCL2 | 1.574 | 0.160 |
Data presented as fold change calculated from ΔΔ-CT values, unpaired two-tailed t-test used as statistical method.