Table 4.

Main data regarding adjuvant chemoradiotherapy for gastric cancer

Ref.	Study design	No. of patients	Survival (P value)	Disease free survival (P value)	Recurrence (P value)	Loco-regional recurrence (P value)
Moertel et al[44], 1984	RCT surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 39	At 5 yr	At 5 yr	-	S vs SCRT
		SCRT: 23	S < SCRT	S < SCRT		(NS)
			(0.05)	(0.02)
Allum et al[45], 1989 BSCG	RCT surgery alone (S) vs surgery + chemoradiotherapy (SCRT) vs surgery + chemotherapy (SCT)	S: 145	At 5 yr	-	-	S vs SCRT (NS)
		SCRT: 153	S vs SCRT			S vs SCT (NS)
		SCT: 138	vs CT (NS)
Hallissey et al[46], 1994 BSCG	RCT surgery alone (S) vs surgery + chemoradiotherapy (SCRT) vs surgery + chemotherapy (SCT)	S: 145	At 5 yr	-	-	-
		SCRT: 153	S vs SCRT
		SCT: 138	vs CT (NS)
Macdonald et al[42], 2001INT-0116	RCT surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 275	At 3 yr	At 3 yr	At 3 yr	At 3 yr
		SCRT: 281	S < SCRT	S < SCRT	S > SCRT	S > SCRT
			(0.005)	(0.001)	(0.001)	(0.0001)
Dikken et al[49], 2010	Retrospective surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 694	At 24 mo S vs SCRT (NS)	At 24 mo	-	At 24 mo
		SCRT: 91		S vs SCRT (NS)		S > SCRT (0.0015)
Kim et al[51], 2005	Observational surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 446	At 5 yr	At 5 yr	-	At 5 yr
		SCRT: 544	S < SCRT	S < SCRT		S > SCRT
			(0.01)	(0.01)		(0.005)
Smalley et al[53], 2012	RCT surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 227	At 10 yr	At 10 yr	At 10 yr	Ar 10 yr
INT-0116		SCRT: 282	S < SCRT	S < SCRT	S > SCRT	S > SCRT
			(0.0046)	(0.001)	(0.006)	(0.0001)
Fiorica et al[54], 2007	Meta-analysis surgery alone (S) vs surgery + chemoradiotherapy (SCRT)	S: 424	At 5 yr	-	-	-
		SCRT: 444	S < SCRt
			(0.00001)
Lee et al[55], 2011	RCT surgery + chemoradiotherapy (SCRT) vs surgery + chemotherapy (SC)	SCRT: 230	-	At 3 yr	SCRT vs SC (NS)	SCRT vs SC (NS)
		SC: 228		SCRT vs SC (NS)

RCT: Randomized controlled trial; NS: Not significant.