Table 2.
In silico prediction of chromosomal MDR transporter systems involved in resistance to antimicrobial agents in representative rhodococcal species (sharing > 75% identity) and their relation to Mycobacterium tuberculosis H37Rv transporters.
| Type of transporter | Rhodococcal strain | ||||
|---|---|---|---|---|---|
| R. equi 103S | R. erythropolis PR4 | R. jostii RHA1 | R. opacus B4 | M. tuberculosis H37Rv | |
| PUTATIVE ABC TRANSPORTER INTEGRAL MEMBRANE SUBUNIT | |||||
| REQ_11220 | RER_56560 (71%) | RHA1_ro02603 (69%) | ROP_03190 (77%) | – | |
| REQ_12170 | RER_43530 (84%) | – | – | – | |
| REQ_20440 | RHA1_ro06840 (83%) | ROP_68250 (83%) | – | ||
| REQ_24790 | RER_32730 (77%) | RHA1_ro00945 (80%) | ROP_06760 (80%) | Rv1686c (64%) | |
| REQ_30790 | RER_46100 (75%) | RHA1_ro02603 (50%) | – | ||
| RER_44380 | RHA1_ro04792 (88%) | ROP_48830 (88%) | – | ||
| PUTATIVE ABC TRANSPORTER INTEGRAL MEMBRANE/ATPase SUBUNITS | |||||
| REQ_03250 | RER_03410 (72%) | RHA1_ro04169 (79%) | ROP_40980 (79%) | – | |
| REQ_14720 | RER_41210 (74%) | RHA1_ro06013 (78%) | ROP_60720 (78%) | Rv0194 (43%) | |
| RHA1_ro01004 | ROP_07300 (97%) | Rv1819c (52%) | |||
| PUTATIVE MFS TRANSPORTER | |||||
| REQ_00410 | RHA1_ro05096 (75%) | ROP_51570 (77%) | – | ||
| REQ_08920 | RER_55050 (75%) | Rv1634 (53%) | |||
| REQ_09900 | RER_46140 (79%) | RHA1_ro04995 (78%) | ROP_50560 (80%) | – | |
| REQ_13270 | RER_55220 (78%) | – | |||
| REQ_15920 | RHA1_ro01594 (76%) | ROP_12980 (77%) | Rv1258c (55%) | ||
| REQ_18780 | RHA1_ro06618 (75%) | ROP_66540 (75%) | EfpA (53%) | ||
| REQ_19100 | RHA1_ro06636 (83%) | ROP_66710 (83%) | – | ||
| REQ_20430 | RHA1_ro05369 (80%) | ROP_54620 (80%) | – | ||
| REQ_23090 | RER_31910 (75%) | RHA1_ro00861 (75%) | ROP_05990 (75%) | – | |
| REQ_27500 | RER_35250 (77%) | RHA1_ro01063 (78%) | ROP_07910 (77%) | – | |
| REQ_30590 | RER_38560 (80%) | RHA1_ro01413 (83%) | ROP_11240 (84%) | Rv_2508c (51%) | |
| REQ_36620 | RER_17440 (75%) | RHA1_ro01949 (76%) | Rv_0783c (51%) | ||
| REQ_38480 | RER_15430 (79%) | – | |||
| REQ_39850 | RER_13960 (85%) | RHA1_ro05519 (87%) | ROP_55930 (87%) | – | |
| REQ_45350 | RHA1_ro04268 (79%) | ROP_41810 (79%) | – | ||
| RER_13470 | RHA1_ro04142 (79%) | ROP_40760 (79%) | – | ||
| RER_19430 | RHA1_ro05093 (83%) | ROP_51550 (82%) | Rv2459 (35%) | ||
| RER_39310 | RHA1_ro02360 (82%) | ROP_20740 (85%) | – | ||
| RER_55700 | RHA1_ro04268 (78%) | ROP_41810 (78%) | – | ||
| PUTATIVE SMR PROTEIN | |||||
| REQ_07770 | RER_09840 (81%) | RHA1_ro04738 (80%) | ROP_48320 (80%) | – | |
| PUTATIVE MATE EFFLUX FAMILY PROTEIN | |||||
| REQ_19210 | RER_26360 (74%) | RHA1_ro06648 (78%) | ROP_66870 (77%) | Rv_2836c (63%) | |
| PUTATIVE RND FAMILY PROTEIN | |||||
| mmpL1 | REQ_03240 | RER_03400 (78%) | RHA1_ro04168 (80%) | ROP_40970 (79%) | – |
| mmpL2 | REQ_22980 | RER_31970 (77%) | RHA1_ro03267 (79%) | ROP_27830 (80%) | – |
| mmpL3 | REQ_34640 | RER_09760 (74%) | RHA1_ro11238 (74%) | ROP_00400 (76%) | MmpL11 (30%) |
| mmpL4 | REQ_34730 | RHA1_ro06222 (73%) | ROP_62810 (73%) | Rv0206c (40%) | |
| mmpL6 | REQ_44510 | RER_52340 (76%) | RHA1_ro02326 (78%) | ROP_20440 (77%) | – |
The identity percentage shown was calculated relatively to R. equi 103S or R. erythropolis PR4 genomes.