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. 2014 Apr 4;5:66. doi: 10.3389/fphar.2014.00066

FIGURE 1.

FIGURE 1

Age dependent behavioral responses of flies overexpressing ferritin subunits pan-neuronally. Elicited escape response of flies was assessed on a weekly basis. The first bar on each graph corresponds to control (uninfected from Wolbachia) flies carrying the ferritin subunit transgenes without the elav-Gal4 driver. Bars 2 and 3 correspond to flies overexpressing Fer1HCH and Fer2LCH, respectively. Bars 4 and 5 correspond to flies simultaneously overexpressing both Fer1HCH and Fer2LCH from recombinant transgenes on the third and X chromosomes, respectively. (A) Flies expressing either the heavy or the light chain alone did not exhibit statistical differences from controls in their escape response until the fifth week and showed a moderate twofold increase in their response time on week 6 (p < 0.05). In contrast, flies overexpressing both ferritin subunits showed a significant impairment at 5 and 6 weeks of age (p < 0.001). (B) Only flies overexpressing both ferritin subunits from the X-chromosome were significantly compromised when responding in the horizontal direction in weeks 5 and 6 (p < 0.001).