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. 2014 Apr 4;5:66. doi: 10.3389/fphar.2014.00066

FIGURE 2.

FIGURE 2

Plastic embedded sections from 40-day old fly heads stained with toluidine blue. (A) Control flies show no signs of degeneration at this age (grown at 25°C). (B) Flies overexpressing ferritin derived from UAS-Fer1HCH, UAS-Fer2LCH; +; + mothers crossed to Elav-Gal4; +; + fathers show extensive neurodegeneration. (C,D) Flies overexpressing single ferritin subunits show no signs of neurodegeneration. (E) Flies overexpressing ferritin from the recombinant insertions on the third Chromosome also show no apparent neurodegeneration. (F) Close-up of image shown in (B). Filled arrowheads denote the absence of single neuronal cell bodies lined up in the optic medulla. Horizontal arrows indicate areas of extensive neuronal damage.