Figure 1.

Overall load and features of genomic lesions in the discovery panel. (A) Combined load of somatically acquired nonsilent mutations and CNA identified in the FR-CLL discovery panel. (B) Type of mutations. (C) Nucleotide targeting of point mutations. (D) Mutation frequency at specific dinucleotides (red bars). Asterisks denote statistically significant differences in over-represented changes compared with the expected frequencies (gray bars), as assessed by a Poisson distribution after correction for multiple hypotheses.