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. 2014 Feb 18;123(15):2378–2388. doi: 10.1182/blood-2013-10-534271

Figure 3.

Figure 3

Features of FAT1 mutations. (A) Schematic representation of the FAT1 (upper) gene and (lower) protein, with its conserved functional domains. Triangles indicate the position of the mutations found in FR-CLL. (B) Mutual relationship of FAT1 mutations with other gene alterations in FR-CLL. In the heat map, rows correspond to identical genes and columns represent individual patients, color-coded based on the gene status (white indicates WT; gray indicates mutations and/or deletion of TP53, mutations and/or deletion of BIRC3, mutations of SF3B1, and mutations of NOTCH1). (C) Prevalence of FAT1 mutations in FR-CLL vs unselected CLL at diagnosis.