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. Author manuscript; available in PMC: 2014 Apr 11.
Published in final edited form as: Trends Immunol. 2012 Jul 6;33(9):429–436. doi: 10.1016/j.it.2012.05.005

Figure 3.

Figure 3

Model for germline specificity of the T cell receptor (TCR) V region repertoire for MHC. TCR–MHC binding footprints, represented by the TCR CDR loops only, are shown for several different TCR germline types that appear illustrative of distinct specificities of each type of V region for each type of MHC. Note that, for the example of Vβ8.2 recognizing three different types of MHC, the chemistry of the interactions differ (cartoon blowups) yet within each MHC the interactions are similar.