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. Author manuscript; available in PMC: 2014 Apr 11.
Published in final edited form as: Trends Immunol. 2012 Jul 6;33(9):429–436. doi: 10.1016/j.it.2012.05.005

Figure 4.

Figure 4

Constraints on germline-encoded T cell receptor (TCR)–MHC engagement imposed by co-receptors. (a) Model of a signaling complex of TCR–CD3–peptide–MHC and CD8 intended to indicate the geometric constraints imposed by simultaneous association of all of the subunits that might limit the TCR–pMHC docking angle. (b) Docking footprints of signaling-productive, presumably germline-encoded TCR docking footprints that are highly convergent shown compared to a non-signaling docking footprint that has potentially exceeded the geometric tolerances highlighted in panel A.