Figure 1.
Essential characteristics of the CCM. a, Interareal and interlaminar excitatory projections, highlighting projections thought to determine the timing of CSD in specific laminae. Projections are numbered in order of temporal precedence for clarity (adapted from Gilbert, 1983). b, Lateral, recurrent excitatory and inhibitory projections. GABAergic projections exerting inhibitory influence are depicted in red. Glutamatergic projections exerting excitatory influence are depicted in blue. Pools of superficial and deep layer pyramidal neurons are modeled separately to account for differences in GABAA and GABAB receptor distributions (adapted from Douglas and Martin, 1991).