Figure 3.
Noninvasive detection of genetic mutations. One-dimensional magnetic resonance spectroscopy with use of specialized spectral-editing sequence for the detection of 2HG as demonstrated in a secondary glioblastoma patient with IDH1R132H mutation (A), in comparison with the spectra from a healthy volunteer with wt IDH1 (B). Figure reprinted (adapted) with permission from Andronesi OC, Kim GS, Gerstner E et al. Detection of 2HG in IDH-mutated glioma patients by in vivo spectral editing and two-dimensional correlation magnetic resonance spectroscopy. Sci Transl Med 2012;4:116ra4.
Abbreviations: a.u., arbitrary units; GABA, γ-aminobutyric acid; Gln, glutamine; Glu, glutamate; 2HG, 2-hydroxyglutarate; I, signal intensity; MM, denotes contamination of GABA signal with macromolecule signal; wt, wild-type.