Table 2:

Hemodynamic Profiles of Patients with Sickle Cell Disease with or without Pulmonary Hypertension: Three Cohorts^*

	PH	No PH	P Value
NIH cohort	n = 56	n = 30
CVP, mm Hg	10 ± 5	6 ± 3	<0.001
mPAP, mm Hg	36 ± 9	19 ± 4	<0.001
PAWP, mm Hg	16 ± 5	12 ± 3	<0.001
CO, L/min	8 ± 3	9 ± 2	0.14
CI, L/min/m2	5 ± 1	5 ± 1	0.063
PVR, dyn⋅s⋅cm−5	229 ± 149	74 ± 38	<0.001
French cohort	n = 24	n = 72
CVP, mm Hg	10 ± 6	7 ± 2	<0.001
mPAP, mm Hg	30 ± 6	19 ± 3	<0.001
PAWP, mm Hg	16 ± 7	11 ± 3	<0.001
CO, L/min	8.7 ± 1.9	8.4 ± 2.1	0.60
PVR, dyn⋅s⋅cm−5	138 ± 58	72 ± 26	<0.001
Brazilian cohort†	n = 8	n = 18
mPAP, mm Hg	33.1 ± 8.9	18.7 ± 2.8	<0.001
PAWP, mm Hg	16.0 ± 5.7	13.3 ± 2	0.07
CI, L/min/m2	5 ± 1.36	4.9 ± 1.7	0.85
PVR, dyn⋅s⋅cm−5	179 ± 120	64 ± 48	0.002

Definition of abbreviations: CI = cardiac index; CO = cardiac output; CVP = central venous pressure; mPAP = mean pulmonary artery pressure; NIH = National Institutes of Health; PAWP = pulmonary artery wedge pressure; PVR = pulmonary vascular resistance.

^*From References 2, 3, and 12.

^†CVP data not provided for Brazilian cohort.