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β-Catenin is a multifunctional protein that localizes at cell-cell contacts, the nucleus, cytosol and centrosomes. Cortical proteins and Wnt signaling components have been implicated in regulating cell cycle progression. Additionally, β-catenin destruction pathway proteins (APC, Axin, GSK3β) are also located at the centrosome and are involved in similar functions as β-catenin suggesting a cross-talk between these 3 distinct cellular pools of proteins.
