Table 1.

Main rules for aggregation of events into states

State code*	State	Type of event to aggregate (time-lapse between two events for aggregation)	Dating
A	AP	≥ 1 pathology investigations (less that 3 months apart)	Sampling Date
			If several:
			Start: date of first investigation
			End: date of last investigation
C	SURG	≥ 1 surgical acts (less than 3 months apart)	Date of the act
			If several:
			Start: date of first surgery
			End: date of last surgery
D	SURG_AP	≥ 1 surgical acts (less than 3 months) apart AND ≥ 1 pathology investigations	Date of the act, or else date of the sample.
			If several:
			Start: date of first surgery
			End: date of last surgery
N	CT_NEO	≥ 1 administrations of chemotherapy occurring before the first surgery	Start: date of the first administration
			End: date of the last administration
K	CT	≥ 1 administrations of chemotherapy (less than 6 months apart)	Start: date of the first administration
			End: date of the last administration
R	RT	≥ 1 radiotherapy sessions (less than 1 month apart)	Start: date of the first session
			End: date of the last session
O	CT_RT	Period of concomitant radiotherapy and chemotherapy	Start: date of the first session of intercurrent RT or CT
			End: date of the last session of intercurrent RT or CT

*Each state is recoded by a character so as to represent the overall sequence in the form of an ordered chain of characters.