TABLE II.
SNPs Selected for Association Analysis
| CHR | SNP | Location (build hg18) | MinorAllele | ObsMAF | MAF-HapMap-CEU | HWE P-value | Nearest gene | Prior associated phenotype (reference) |
|---|---|---|---|---|---|---|---|---|
| 1 | rs1625579 | 98502934 | C | 0.16 | 0.16 | 0.24 | MIR137 | SCZ Ripke et al. [2011] |
| 2 | rs17662626 | 193984621 | G | 0.08 | 0.12 | 1 | PCGEM1 | SCZ Ripke et al. [2011] |
| 2 | rs1344706 | 185778428 | C | 0.39 | 0.39 | 0.37 | ZNF804A | SCZ O’Donovan et al. [2008]; Ripke et al. [2011] |
| 2 | rs12185688 | 191814608 | C | 0.13 | 0.15 | 0.79 | GLS | POC Glutamine/Glutamate ratio Ongur et al. [2011] |
| 2 | rs13000464 | 191786868 | T | 0.48 | 0.42 | 0.33 | GLS | POC Glutamine/Glutamateratio Ongur et al. [2011] |
| 2 | rs17748089 | 191789907 | A | 0.05 | 0.06 | 1 | GLS | POC Glutamine/Glutamateratio Ongur et al. [2011] |
| 4 | rs4279178 | 47068580 | A | 0.46 | 0.47 | 1 | GABRB1 | SA/BPD Craddock et al. [2010]; Porjesz et al. [2002] |
| 6 | rs9371601 | 152790573 | A | 0.38 | 0.33 | 0.03 | SYNE1 | BPD Sklar et al. [2011] |
| 8 | rs7004633 | 89760311 | G | 0.23 | 0.17 | 1 | MMP16 | SCZ Ripke et al. [2011] |
| 10 | rs10994397 | 62279124 | T | 0.06 | 0.08 | 0.19 | ANK3 | BPD Sklar et al. [2011] |
| 10 | rs7914558 | 104775908 | A | 0.39 | 0.39 | 0.16 | CNNM2 | SCZ Ripke et al. [2011] |
| 10 | rs11191580 | 104906211 | G | 0.08 | 0.08 | 0.22 | NT5C2 | SCZ Ripke et al. [2011] |
| 11 | rs12576775 | 79077193 | C | 0.17 | 0.17 | 1 | ODZ4 | BPD Sklar et al. [2011] |
| 11 | rs548181 | 125461709 | A | 0.12 | 0.11 | 1 | STT3A | SCZ Ripke et al. [2011] |
| 12 | rs4765905 | 2349584 | C | 0.33 | 0.35 | 0.27 | CACNA1C | BPD/SCZ Sklar et al. [2011] |
| 12 | rs4765913 | 2419896 | A | 0.21 | 0.18 | 0.47 | CACNA1C | BPD/SCZ Ripke et al. [2011]; Sklar et al. [2011] |
| 15 | rs16969968 | 78882925 | A | 0.37 | 0.38 | 1 | CHRNA5 | Nicotine Dependence Bousman et al. [2012] |
| 15 | rs6495308 | 78907656 | G | 0.22 | 0.21 | 1 | CHRNA5 | Nicotine Dependence Bousman et al. [2012] |
| 18 | rs12966547 | 52752017 | A | 0.40 | 0.42 | 0.44 | CCDC68 | SCZ [Ripke et al., 2011 |
| 18 | rs17512836 | 53194961 | G | 0.03 | 0.03 | 1 | TCF4 | SCZ Quednow et al. [2012a]; Quednow et al. [2012b]; Ripke et al. [2011] |
| 18 | rs9960767 | 53155002 | G | 0.04 | 0.07 | 1 | TCF4 | SCZ Quednow et al. [2012a]; Quednow et al. [2012b]; Ripke et al. [2011] |
CHR, chromosome; HWE, Hardy–Weinberg equilibrium; MAF, minor allele frequency; MAF-HapMap-CEU, minor allele frequency in the HapMap-CEU sample; ObsMAF, observed minor allele frequency; POC, parieto-occipital cortex; SCZ, schizophrenia; BPD, bipolar disorder.