Table 1.

Antiprion potency for AMT analogs.

Cmpd	R =	X =	EC50 ± SEM(nM)[a]	n[B]
1	Phenyl	CH3	1290 ± 122	85
12	pyridin-4-yl	CH3	87 ± 43	3
13	pyridin-4-yl N-oxide	CH3	559 ± 120	3
14	2-Me-pyridin-4-yl	CH3	400 ± 61	3
15	pyridin-3-yl	CH3	68 ± 13	5
16	pyridin-3-yl N-oxide	CH3	203 ± 10	3
17	2-Me-pyridin-3-yl	CH3	618 ± 54	3
18		CH3	89 ± 35	3
19		CH3	2133 ± 226	3
20	N-Me-piperazinyl	CH3	840 ± 132	3
21	morpholino	CH3	51 ± 7	3
22	phenyl	MeOCH2CH2O-	>10,000	3
23	phenyl	Me2N-	699 ± 87	3
24	phenyl	N-Me-piperazinyl	1183 ± 206	5

^[a]antiprion potency in ScN2a-cl3 cells by ELISA; SEM is calculated as standard deviation divided by the square root of n.

^[b]number of repetitions.