Table 3.

Antiprion potency for AMT analogs with amide C-groups.

Cmpd	R1 =	R2 =	EC50 ± SEM(nM)[a]	n[B]
34	phenyl	cyclopropyl	248 ± 67	4
35	phenyl	CH3	119 ± 10	3
36	phenyl	MeOCH2-	1588 ± 295	3
37	phenyl	i-Pr	>10,000	3
38	phenyl	phenyl	>10,000	3
39	pyridin-4-yl	cyclopropyl	173 ± 16	3
40	2-Me-pyridin-3-yl	cyclopropyl	>10,000	3
41	4-Me2N-pyridin-3-yl	cyclopropyl	109 ± 12	3
42		cyclopropyl	>10,000	3
43		cyclopropyl	>10,000	3
44		cyclopropyl	1315 ± 233	4
45		cyclopropyl	682 ± 100	3
46		cyclopropyl	118 ± 11	3
47		cyclopropyl	70 ± 23	4

^[a]antiprion potency in ScN2a-cl3 cells by ELISA; SEM is calculated as standard deviation divided by the square root of n.

^[b]number of repetitions.