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. Author manuscript; available in PMC: 2014 Apr 11.
Published in final edited form as: Alzheimers Dement. 2011 Nov 2;8(6):574–583. doi: 10.1016/j.jalz.2011.05.2429

Figure 1. Alzheimer’s disease whole-mount preparations of isolated microvessel-associated amyloid deposits stained by thioflavine-S.

Figure 1

A) A tuft of cortical microvessels walls revealed as detergent (SDS) insoluble cross-linked extracellular matrix remnants demonstrating a wide range of amyloid core deposits intimately associated with the basal lamina. The early amyloid deposits are small, flat and ellipsoidal. In more advanced deposits, the amyloid deposits become spherical and completely surround the vascular wall. The continuous accretion of fibrillar Aβ onto the surface of the amyloid sphere by glial cells may eventually obliterate the microvessel, thereby compromising blood supply. B and C) Tufts of capillaries and arterioles with numerous amyloid cores attached to the vascular basal lamina. Note that in some instances the spherical amyloid cores are sparse while in other instances they are distributed in a rosary-like succession. For detailed technical information and interpretation see reference [11]. Figure A reproduced with permission from the Publisher: Proceeding of the National Academy of Sciences, USA. Magnification: A = 100X; B = 200X; C = 400X.