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Distribution of EC50 values for the final 6 chemical scaffolds confirmed in T98G cells, based on potency testing of confirmed SPC hits and related analogs.
| Scaffold | Murcko Fragment | Compounds tested (n) | Compounds with EC50 <1 μM (n) | Compounds with EC50 = 1–10 μM (n) |
|---|---|---|---|---|
| Amide |
|
159 | 5 | 8 |
| Aminothiazole |
|
26 | 5 | 3 |
| Chromene |
|
5 | 5 | 0 |
| Fused Pyrrole |
|
14 | 6 | 3 |
| Sulfonamide |
|
60 | 4 | 4 |
| Piperazine |
|
21 | 3 | 1 |
