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Preliminary SAR evaluating EC50 values by ELISA and LC50 values by calcein for selected amide analogs that lower levels of PrPC in T98G cells.
| ||||
|---|---|---|---|---|
| Compound | R1 | EC50 ± SEM (μM) | LC50 (μM) | Replicates (n) |
| IND61769 |
|
2.33 ± 0.30 | >10 | 4 |
| IND6612 |
|
3.13 ± 0.35 | >10 | 3 |
| IND126416 |
|
>10 | >10 | 3 |
| IND116065 |
|
0.44 ± 0.11 | >10 | 6 |
