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. Author manuscript; available in PMC: 2015 Mar 15.
Published in final edited form as: Bioorg Med Chem. 2014 Jan 9;22(6):1960–1972. doi: 10.1016/j.bmc.2014.01.001

Table 5.

Stability of 8 confirmed SPC hits tested in EC50 assays, representing 6 scaffolds, in mouse and human liver microsomes.

Compound # Structure t1/2 in min (% remaining after 60-min incubation)
Mouse Human
IND8541 12 graphic file with name nihms569516t43.jpg 1.9 (0.1) 9.7 (1.3)
IND30802 22 graphic file with name nihms569516t44.jpg 3.0 (0.1) 6.0 (0.1)
IND87406 6 graphic file with name nihms569516t45.jpg 2.8 (0.0) 16.7 (8.3)
IND116065 7 graphic file with name nihms569516t46.jpg 18.5 (5.8) 10.3 (4.6)
IND116071 29 graphic file with name nihms569516t47.jpg 0.7 (0) 2.0 (0)
IND116088 18 graphic file with name nihms569516t48.jpg 3.2 (0.1) 9.9 (1.6)
IND126328 9 graphic file with name nihms569516t49.jpg 4.5 (0.5) 9.6 (1.5)
IND126339 24 graphic file with name nihms569516t50.jpg 1.6 (0.0) 4.5 (1.0)