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. 2014 Apr 7;10:587–598. doi: 10.2147/NDT.S39692

Figure 2.

Figure 2

Bup/nx induction (day 1).

Notes: aUse higher dose (4 mg bup) in patients in severe withdrawal; bno improvement in withdrawal symptoms or persisting signs of mild-to-moderate withdrawal (COWS >4); cGunderson et al60 suggests going up to 16 mg on the first day. Data sources: Center of Addiction and Mental Health,33 Substance Abuse and Mental Health Services Administration,34 Community Care Behavioral Health Organization,45 Tompkins et al,59 Gunderson et al,60 and Kraus et al.73

Abbreviations: Bup/nx, buprenorphine–naloxone; COWS, Clinical Opioid Withdrawal Scale; NSAIDs, nonsteroidal anti-inflammatory drugs; bup, buprenorphine.