Figure 5. Effect of DCA and ADM alone and in combination on growth of HCC-LM₃ xenografts in nude mice (n = 8 in each group).

(A) Time course of tumor volumes. Treatment with DCA/ADM combination resulted in enhanced efficacy compared with either agent alone. (B) Images, and (C) tumor weights and inhibition rates of excised tumors show enhanced efficacy of the combined treatment as compared with either agent alone. * and $ indicate statistical significance versus control and groups treated with either agent alone (p<0.05).