Table 2. Clinical and pathological status of donors and recipients.
Group | Pair No. | Major complication of recipient | Pathological findings | Immunosuppression status | |
Lower NTCR Group | Donor | (-) | |||
1 | Recipient | Chronic hepatitis | Mild interface hepatitis | Tacrolimus: twice a day | |
de novo HBV | Micophenolate mofetil | ||||
Donor | (-) | ||||
2 | Recipient | Mild interface hepatitis | Tacrolimus: twice a day | ||
Micophenolate mofetil | |||||
Steroid | |||||
Donor | (-) | ||||
3 | Recipient | Tacrolimus: twice a day | |||
HV stenosis | Marked bridging fibrosis | Micophenolate mofetil | |||
Steroid | |||||
Donor | (-) | ||||
4 | Recipient | Unstable liver function | Mild lobular hepatitis | Cyclosporine: twice a day | |
Micophenolate mofetil | |||||
Comparable NTCR Group | Donor | Moderate steatosis | |||
5 | Recipient | de novo HBV | (-) | Cyclosporine: twice a day | |
(seroconversion) | Micophenolate mofetil | ||||
Donor | |||||
6 | Recipient | Liver dysfunction | Marked bridging fibrosis | Tacrolimus: twice a day | |
HV stenosis | Micophenolate mofetil | ||||
Steroid | |||||
7 | Donor | (-) | |||
Recipient | None | Mild interface hepatitis | Tacrolimus: twice a day | ||
Donor | Moderate steatosis | ||||
8 | (NASH suspected) | ||||
Recipient | Biliary stricture | Canalicular cholestasis | Cyclosporine: twice a day | ||
Donor | (-) | ||||
9 | Recipient | HV stenosis | Mild interface hepatitis | Cyclosporine: twice a day | |
Micophenolate mofetil | |||||
10 | Donor | (-) | |||
Recipient | None | (-) | Complete cessation | ||
11 | Donor | (-) | |||
Recipient | None | (-) | Tacrolimus: once a week | ||
Donor | Moderate steatosis | ||||
12 | Recipient | Unstable liver function | (-) | Tacrolimus: twice a day | |
Micophenolate mofetil |
HBV: hepatitis B virus, HV: hepatic vein, NTCR: normalized telomere centromere ratio, NASH: none-alcoholic steatotic hepatitis, (-): almost normal.
Lower NTCR group: Median NTCRs of the recipient hepatocyte was significantly lower than those of the donor.
Compatible NTCR group: Median NTCRs of the recipient hepatocyte was not significantly lower nor higher than those of the donor.