Table 3. Association between WMH volume and measures of BP and ICA blood velocity (standardized β (p value, FDR correctedpvalues)).

Models accounted for all covariates.

Predicting WMH volume from measures of BP
		Covariates
Measures of BP at waves 1 or 2	BP Measures	ICV	Sex	Age in days
Systolic BP, wave 1	0.08 (0.043,0.057)	0.12 (0.021)	0.08 (0.126)	0.15 (<0.0001)
Systolic BP, wave 2	0.06 (0.113,0.248)	0.12 (0.019)	0.08 (0.123)	0.14 (<0.0001)
Mean BP, wave 1	0.09 (0.021,0.057)	0.11 (0.023)	0.08 (0.118)	0.15 (<0.0001)
Mean BP, wave 2	0.06 (0.144,0.248)	0.12 (0.02)	0.08 (0.131)	0.14 (<0.0001)
Diastolic BP, wave 1	0.08 (0.036,0.057)	0.11 (0.025)	0.08 (0.121)	0.15 (<0.0001)
Diastolic BP, wave 2	0.04 (0.306,0.306)	0.12 (0.021)	0.08 (0.123)	0.14 (<0.0001)
Pulse pressure, wave 1	0.04 (0.249,0.249)	0.12 (0.02)	0.07 (0.142)	0.14 (<0.0001)
Pulse pressure, wave 2	0.05 (0.186,0.248)	0.12 (0.021)	0.08 (0.131)	0.14 (<0.0001)

Predicting WMH volume from measures of ICA velocity
		Covariates
Measure of ICA velocity at wave 2 ICA velocity measures		ICV	Sex	Age in days	Hypertension
Systolic velocity	0.04 (0.343,0.428)	0.13 (0.011)	0.09 (0.085)	0.14 (<0.0001)	0.13 (<0.0001)
Mean velocity	0.00(0.990,0.990)	0.13 (0.011)	0.09 (0.086)	0.13 (<0.0001)	0.13 (<0.0001)
Diastolic velocity	−0.05 (0.178,0.283)	0.13 (0.012)	0.09 (0.075)	0.13 (0.001)	0.13 (0.001)
Pulsatility index	0.09 (0.016,0.08)	0.12 (0.014)	0.10 (0.047)	0.13 (<0.0001)	0.12 (0.002)
Resistivity index	0.07 (0.054,0.135)	0.12 (0.015)	0.09 (0.066)	0.14 (<0.0001)	0.13 (0.001)

Note: Dependent variables were measures of WMH while independent variables were measures of ICA velocities and of BP. Each row represents a separate model which controlled for ICV and demographic variables. Health variables’ inclusion used stepwise method and only those that passed the Akaike Information Criterion test appeared in the final model above.