Figure 8. Sequence alignment of monkey and human α6 nAChR subunits.

A, Sequence alignment of monkey and human α6 subunits identified a single residue in the extracellular ligand-binding domain at position 100 that differed between the two species. The asterisks identify residues that have previously shown to be important for α-Ctx binding [47], [48], [49]. Note that these residues are strictly conserved between the two species. TM indicates the transmembrane domains.