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. 2014 Apr 11;9(4):e94213. doi: 10.1371/journal.pone.0094213

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© 2014 Hassan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. PC-10 cells were incubated at 42.5°C for 0, 1, 3 and 6 h. Bax was co-immunoprecipitated from 2 mg total protein and Bcl-xL, Bcl-2 and Ku70 were detected in the immunoprecipitant by western analysis. Hyperthermia induces Bax up-regulation and Bax dissociation from Bcl2 and enhances association between Bax and Ku70, while no effect on the Bax/Bcl-xL association. In contrast, Ku70 was co-immunoprecipitated from similar cell lysates. Bax and Ku80 are shown in the immunoprecipitant. B. After hyperthermia, total Ku70 levels showed no changes, but association between Ku70 and Bax was enhanced.