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. 2014 Apr 11;9(4):e94331. doi: 10.1371/journal.pone.0094331

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© 2014 Peng et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Sequence profiles of BK for (A) all 22 considered variants, (B) 6 DEC type variants, (C) 7 ERL type variants, and (D) 9 VYR type variants. Profile includes sequence conservation (uppermost plot), sites of mutations between different variants (gray), regions inserted/deleted through alternative splicing (black), majority-vote based (a given annotation is considered if it occurs in at least 50% of variants at a given position in the chain) profiles for putative disorder (red), MoRFs (pink), globular domains (green), and four types of ELMs (blue). ELMs include cleavage sites (CLV), ligand binding sites (LIG), sites of posttranslational modification (MOD) and subcellular targeting sites (TRG).