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. 2014 Apr 11;9(4):e94487. doi: 10.1371/journal.pone.0094487

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© 2014 Okada et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative findings of immunohistochemical analysis of EpCAM in clinical thyroid cancer specimens; a, membranous and cytoplasmic staining in papillary thyroid cancer; b, membranous and cytoplasmic staining in follicular thyroid cancer; c, cytoplasmic and nuclear staining in anaplastic thyroid cancer; d, nuclear staining in anaplastic thyroid cancer. Scale bar = 100 µm. (B) Localization of EpCAM in the differentiated thyroid cancers and the anaplastic thyroid cancers in clinical specimens. Blue bars indicate the number of tumors showed membranous (M) or cytoplasmic (C) expression of EpCAM, and red bars indicate the number of tumors showed nuclear (N) expression.