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. 2014 Apr 11;9(4):e94487. doi: 10.1371/journal.pone.0094487

Figure 8. Immunohistochemical analysis of expression of CD44s and CD44v6 in clinical thyroid cancers.

Figure 8

(A) Representative findings of immunohistochemical analysis of CD44s (a-d) and CD44v6 (e-h) in clinical thyroid cancer specimens. CD44s (upper panel); a, strong staining (3+) in papillary thyroid cancer; b, strong staining (3+) in follicular thyroid cancer; c, weak staining (1+) in anaplastic thyroid cancer, d, weak staining (1+) in anaplastic thyroid cancer. CD44v6 (lower panel); e, weak staining (1+) in papillary thyroid cancer; f, negative staining (0) in follicular thyroid cancer; g, strong staining (3+) in anaplastic thyroid cancer, h, strong staining (3+) in anaplastic thyroid cancer. Scale bar = 100 µm. (B) Association of CD44s and CD44v6 expressions in the differentiated thyroid cancers and the anaplastic thyroid cancers. The expressions of CD44s and CD44v6 of each tumor were classified into four categories according to the intensity of staining as described in the Materials and methods, and the scores are plotted in the graph.