Table 1. Baseline clinical and biochemical characteristics of survivor and non-survivor patients.
| Survivors (n = 73) | Non-survivors (n = 27) | P value | |
| Gender female – n (%) | 12 (16.4) | 11 (40.7) | 0.02 |
| Age (years) - median (p 25-75) | 47 (32–67) | 66 (45–76) | <0.001 |
| Computer tomography classification - n (%) | 0.002 | ||
| Type 1 | 0 | 0 | |
| Type 2 | 21 (28.8) | 3 (11.1) | |
| Type 3 | 13 (17.8) | 5 (18.5) | |
| Type 4 | 10 (13.7) | 6 (22.2) | |
| Type 5 | 26 (35.6) | 5 (18.5) | |
| Type 6 | 3 (4.1) | 8 (29.6) | |
| Temperature (°C) - median (p 25–75) | 37. (35.6–37.3) | 36.0 (35.0–37.0) | 0.12 |
| Sodium (mEq/L)- median (p 25–75) | 139 (138–142) | 141 (135–149) | 0.19 |
| Glycemia (g/dL) - median (p 25–75) | 139 (120–163) | 161 (142–189) | 0.08 |
| Leukocytes - median*103/mm3 (p 25–75) | 14.7 (10.2–19.3) | 18.3 (10.7–23.9) | 0.46 |
| PaO2 (mmHg) - median (p 25–75) | 151 (116–217) | 141 (104–186) | 0.34 |
| PaO2/FI02 ratio - median (p 25–75) | 336 (242–407) | 190 (154–316) | 0.11 |
| Bilirubin (mg/dl) - median (p 25–75) | 0.50 (0.40–0.87) | 0.75 (0.53–1.05) | 0.045 |
| Creatinine (mg/dl) - median (p 25–75) | 0.80 (0.70–0.90) | 0.95 (0.70–1.10) | 0.44 |
| Hemoglobin (g/dL) - median (p 25–75) | 11.4 (10.4–13.0) | 11.1 (9.4–12.3) | 0.87 |
| Glasgow Coma Scale score - median (p 25–75) | 7 (6–8) | 3 (3–6) | <0.00171 |
| Lactic acid (mmol/L) median (p 25–75) | 1.70 (1.23–2.50) | 1.90 (1.15–4.55) | 0.16 |
| Platelets - median*103/mm3 (p 25–75) | 182 (143–252) | 215 (139–264) | 0.48 |
| INR - median (p 25–75) | 1.03 (0.92–1.15) | 1.22 (1.01–1.67) | 0.15 |
| aPTT (seconds) - median (p 25–75) | 28 (25–32) | 26 (25–31) | 0.86 |
| Fibrinogen (mg/dl) - median (p 25–75) | 350 (282–444) | 376 (246–560) | 0.32 |
| APACHE-II score - median (p 25–75) | 19 (17–23) | 26 (25–32) | <0.001 |
| ISS - median (ppe 25–75) | 25 (25–32) | 25 (25–27) | 0.24 |
| ICP (mmHg) - median (p 25–75) | 15 (14–20) | 20 (12–30) | 0.27 |
| CPP (mmHg) - median (p 25–75) | 68 (57–70) | 60 (54–69) | 0.46 |
| TIMP-1 (ng/mL) - median (p 25–75) | 219 (177–258) | 302 (221–474) | <0.001 |
| MMP-9 (ng/mL) - median (p 25–75) | 760 (428–1113) | 948 (357–1180) | 0.62 |
| TNF-alpha (pg/mL) - median (p 25–75) | 9.72 (7.88–13.40) | 13.65 (8.35–22.75) | 0.12 |
| Tissue Factor (pg/mL) - median (p 25–75) | 189 (129–247) | 194 (169–295) | 0.18 |
| PAI-1 (ng/mL) - median (p 25–75) | 64 (32–89) | 65 (39–99) | 0.99 |
P 25–75 = percentile 25th–75th; PaO2 = pressure of arterial oxygen/fraction inspired oxygen; FIO2 = pressure of arterial oxygen/fraction inspired oxygen; ISS = Injury Severity Score; INR = international normalized ratio; aPTT = activated partial thromboplastin time; APACHE II = Acute Physiology and Chronic Health Evaluation; ICP = intracranial pressure; CPP = cerebral perfusion pressure; TIMP = tissue inhibitor of matrix metalloproteinase; MMP = matrix metalloproteinase; TNF = tumor necrosis factor; PAI = plasminogen activator inhibitor