Table 3. Correlation between serum TIMP-1 levels and other baseline clinical and biochemical characteristics.

	TIMP-1 (ng/mL)
APACHE-II score	rho = 0.33; P = 0.001
GCS score	rho = −0.22; P = 0.03
Lactic acid (mmol/L)	rho = 0.24; P = 0.02
TNF-alpha (pg/mL)	rho = 0.53; P<0.001
Tissue Factor (pg/mL)	rho = 0.43; P<0.001
PAI-1 (ng/mL)	rho = 0.06; P = 0.71
Platelets (cells/mm3)	rho = −0.05; P = 0.61
INR	rho = 0.10; P = 0.35
aPTT (seconds)	rho = 0.08; P = 0.49
Fibrinogen (mg/dL)	rho = 0.07; P = 0.59
MMP-9 (ng/mL)	rho = 0.02; P = 0.88

TIMP =  tissue inhibitor of matrix metalloproteinase; GCS =  Glasgow Coma Scale; TNF  =  tumor necrosis factor; PAI  =  plasminogen activator inhibitor; INR  =  international normalized ratio; aPTT  =  activated partial thromboplastin time; MMP  =  matrix metalloproteinase. Bonferroni correction to control the multiple testing problem (0.05/11 = 0.004) was used. Only P-values lower than 0.004 were considered statistically significant.