Table 3. Meta-analysis of the association between cyclin D1 expression and clinicopathological features of colorectal cancer.

Categories	N	Patients	References	Random-effects model		Heterogeneity
				OR (95% CI)	P	Q	I 2	P
Age in years (<60 vs. ≥60)	11	2302	13–14, 17, 20, 22, 24, 31–32, 34–35, 47	0.62 (0.44–0.89)	0.009	32.79	69.5%	<0.001
Tumor size (cm) (<5 vs. ≥5)	6	1064	10, 20, 22, 24, 35, 47	0.64 (0.35–1.16)	0.139	23.81	79.0%	<0.001
T category (T1,2 vs. T3,4)	16	3473	8–10, 14–15, 17–18, 20–22, 24–25, 31, 34–35, 47	0.70 (0.57–0.85)	<0.001	21.24	29.4%	0.129
N category (negative vs. positive)	14	2504	9–10, 14–15, 20–25, 31, 34–35, 47	0.75 (0.60–0.95)	0.016	20.55	36.7%	0.082
Distant metastasis (M0 vs. M1)	9	1376	14, 20, 22–25, 31, 34, 47	0.60 (0.36–0.99)	0.047	23.03	65.3%	0.003
Histology (Well,mod vs. por)	18	3688	8–10, 13–15, 17–18, 20–24, 31–32, 34–35, 47	0.87 (0.71–1.07)	0.178	19.12	11.1%	0.321

Abbreviations: OR: odds ratio; 95% CI: 95% confidence interval; mod: moderate; por: poor; N, number of studies.