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. 2004 May 1;113(9):1307–1317. doi: 10.1172/JCI17323

Figure 3.

Figure 3

Effect of treatment with DC/Ts on the development of gastrointestinal tumors in APC1309 and APCMin_/+ mice. (A) Ten APC1309 mice were sacrificed at the start of treatment (6 weeks of age). Other groups of APC1309 mice that were untreated or treated with IL-12, with a mixture of PEG-treated DCs and PEG-treated tumor T cells (DC-PEG + T-PEG), with DC/Ts alone, or with DC/T + IL-12, were sacrificed at 10 weeks of age. The gastrointestinal tracts were processed as described in the text. The tumors in the entire gastrointestinal tracts were counted under the microscope. Each column represents mean ± SD (error bar) of the number of tumors. *P < 0.05; **P < 0.001. (B) Six APCMin_/+ mice were sacrificed at the start of treatment (6 weeks of age). Other groups of seven APCMin_/+ mice, which were untreated or treated with IL-12, DC/Ts, or DC/T + IL-12, were sacrificed at 10 weeks of age. The tumors in the entire gastrointestinal tracts were counted as described for A. Each column represents mean ± SD (error bar) of the number of tumors. Figures in parentheses show the number of mice examined. *P < 0.01; **P < 0.001.