Table 4.
Osmolality-adjusted urinary concentrations (ng/mL) of phthalate metabolites by FLG genotype, and estimated percentage difference between genotype groups, with corresponding p-values, from final multivariate regression models.
| Phthalate group | Phthalate metabolite | Osmolality-adjusted median (5th, 95th percentiles) | Estimated percent differencea (95% CI) | p-Valuea | |
|---|---|---|---|---|---|
| FLG-null | FLG WT | ||||
| LMW | MEP | 116 (18, 751) | 83 (17, 2202) | 0.4 (–39, 39) | 0.9 |
| MiBP | 77 (31, 201) | 61 (22, 171) | 21 (4, 39) | 0.02 | |
| MnBP | 42 (14, 118) | 29 (9, 89) | 33 (16, 51) | 0.0002 | |
| ΣDBP(i+n) | 156 (65, 383) | 117 (42, 319) | 26 (9, 42) | 0.003 | |
| MBzP | 46 (14, 171) | 37 (10, 157) | 24 (0.2, 47) | 0.05 | |
| HMW | MEHP | 5 (1, 15) | 4 (0.5, 17) | 13 (–12, 37) | 0.3 |
| MEHHP | 29 (12, 79) | 23 (8, 76) | 16 (–5, 37) | 0.1 | |
| MEOHP | 19 (7, 45) | 15 (4, 55) | 20 (–1, 41) | 0.06 | |
| MECPP | 20 (7, 55) | 16 (6, 53) | 14 (–5, 33) | 0.1 | |
| MiNP | 0.7 (0.1, 4) | 0.6 (0.1, 5) | –3 (–36, 30) | 0.8 | |
| MHiNP | 6 (1, 26) | 4 (0.9, 22) | 25 (–2, 52) | 0.07 | |
| MOiNP | 3 (0.7, 13) | 2 (0.4, 11) | 26 (–4, 56) | 0.09 | |
| MCiOP | 8 (3, 55) | 8 (3, 38) | 14 (–7, 35) | 0.2 | |
| ΣDEHPm | 96 (37, 231) | 80 (29, 271) | 16 (–3, 35) | 0.1 | |
| ΣDiNPm | 24 (7, 154) | 21 (6, 95) | 16 (–6, 38) | 0.2 | |
| All shown metabolites were detectable in urine in > 95% of participants, except MiNP (measurable in 49% of men). Abbreviations: LMW, low-molecular-weight phthalates often found in personal care products; HMW, high-molecular-weight phthalates used as plasticizers, infrequently found in personal care products. aData are from multivariate linear regression models using ln-transformed phthalate metabolite concentrations, adjusting for age, smoking, and year of participation; adjusted means are provided in Figure 1. | |||||