. 2014 Jan 24;122(4):418–424. doi: 10.1289/ehp.1307459

Table 5.

Association between traffic-related NO₂ during the first year of life and asthma and wheeze at school age (pooled data).

Gene	Current asthma			Ever asthma			Current wheeze			Ever wheeze			Ever asthma and current wheeze
Gene	n	aOR^a (95% CI)	p^b	n	aOR^a (95% CI)	p^b	n	aOR^a (95% CI)	p^b	n	aOR^a (95% CI)	p^b	n	aOR^a (95% CI)	p^b
GSTP1 rs1138272
TT/TC	789	2.59 (1.43, 4.68)	0.006	769	1.64 (1.06, 2.53)	0.075	772	1.26 (0.71, 2.23)	0.821	775	1.17 (0.82, 1.65)	0.467	757	1.30 (0.67, 2.52)	0.669
CC	3,807	0.95 (0.68, 1.32)	0.766	3,696	1.20 (0.98, 1.48)	0.140	3,711	1.09 (0.82, 1.45)	0.821	3,712	1.09 (0.92, 1.29)	0.467	3,620	1.17 (0.85, 1.61)	0.669
Interaction^c			0.039			0.012			0.096			0.024			0.180
GSTP1 rs1695
GG/GA	2,704	1.43 (1.03, 1.98)	0.096	2,677	1.36 (1.08, 1.70)	0.048	2,695	1.18 (0.86, 1.60)	0.821	2,692	1.11 (0.93, 1.33)	0.467	2,632	1.16 (0.82, 1.65)	0.669
AA	2,008	0.82 (0.52, 1.32)	0.626	1,958	1.12 (0.84, 1.49)	0.432	1,964	1.03 (0.72, 1.46)	0.888	1,951	0.98 (0.79, 1.23)	0.886	1,915	1.09 (0.70, 1.68)	0.709
Interaction^c			0.484			0.087			0.187			0.026			0.436
TNF rs1800629
AA/AG	1,411	1.30 (0.85, 2.00)	0.448	1,372	1.29 (0.94, 1.78)	0.143	1,383	1.04 (0.68, 1.59)	0.888	1,384	1.14 (0.86, 1.49)	0.467	1,350	1.13 (0.70, 1.82)	0.709
GG	3,072	1.07 (0.72, 1.57)	0.766	2,984	1.21 (0.97, 1.52)	0.140	2,988	1.24 (0.92, 1.68)	0.821	2,989	1.09 (0.91, 1.30)	0.467	2,917	1.15 (0.81, 1.63)	0.669
Interaction^c			0.210			0.345			0.096			0.337			0.436
aOR, adjusted odds ratio. ^aFor a 10-μg/m³ increase in NO₂. Adjusted for study, city, intervention, infant sex, maternal age at birth, maternal smoking during pregnancy, environmental tobacco smoke in the home, birth weight, and parental atopy. ^bp-Values were corrected for multiple testing using the Bonferroni method. ^cp-Values for interaction were calculated based on the likelihood-ratio tests between models with and without interaction terms and were corrected for multiple testing using the Bonferroni method.