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. 2014 Apr 4;15:58. doi: 10.1186/1471-2369-15-58

Figure 1.

Figure 1

Db RAS and WT RAS mice developed similar degree of hypertension. A. Systolic blood pressure (BP) of db and WT mice subjected to RAS or sham surgery. Both WT RAS and db RAS experienced similar elevation of systolic BP (WT RAS vs. db RAS, p = ns) compared to their sham control. B. Plasma renin activity in the db and WT mice subjected to RAS or sham surgery as measured by Angiotensin I production. C-D. RT-PCR analysis of Ren1 mRNA as normalized to 18 s in stenotic (C) and contralateral kidneys (D) of db and WT mice subjected to RAS or sham surgery, relative to baseline. E. Ratio of heart weight to tibial length of db and WT mice subjected to RAS or sham surgery. Data are presented as means ± SE. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. WT sham. §§ p < 0.01, §§§ p < 0.001 vs. WT RAS. †† p < 0.01, ††† p < 0.001 vs. db sham. Statistical significance was determined by 2-way ANOVA followed by Tukey adjusted post-hoc comparison.