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. 2014 Jan 15;6(2):367–380. doi: 10.4161/mabs.27830

Table 1. Overview of the human IgGs and RNases used in this study.

IgG Antigen specificity Remarks
MN MN-antigen (tumor associated antigen carbonic anhydrase IX, CA9) Integral plasma membrane glycoprotein
CTX Cholera toxin (control antigen) Soluble protein
Mesothelin Mesothelin-antigen (tumor associated antigen; MSLN) GPI-anchored plasma membrane glycoprotein
X Undisclosed antigen X GPI-anchored
plasma membrane glycoprotein
RNase  
RNase Wild type human pancreatic RNase with truncated carboxy terminus (ΔSVEDST) for increased stability26 according to reference 23
QBI-119 Wild type human pancreatic RNase with truncated carboxy terminus (ΔSVEDST) and with mutations providing RI evasion (R4C, G38R, R39D, L86E, N88R, G89D, R91D, V118C) according to patent WO2005115477
Jo2007 Wild type human pancreatic RNase with truncated carboxy terminus (ΔSVEDST) and with mutations providing RI evasion (R39D, N67D, N88A, G89D, R91D)27

Abbreviations: GPI, glycophosphatidylinositol