Figure 1. Prevalence of mutations in MSL-109 after two rounds of selection of phage by binding to biotinylated CMV strain VR1814 gH/gL followed by competition with 100 nM of MSL-109 IgG. A total of 92 and 88 clones were sequenced for the heavy and light chains respectively. CDR positions with no mutations identified in any of the sequenced clones are omitted for clarity. Mutations occurring in at least 15% of all clones are highlighted in black. MSL-109 CDR positions with somatic mutations are highlighted, with the original germline residues shown in parentheses. Only unambiguous somatic mutations in CDR H3 are indicated in gray.