Table 1. Computational parameters.
| Constructs | Weighted mutation energy | Effect of mutation a | RDOCK scores b |
|---|---|---|---|
| kcal.mol−1 | kcal.mol−1 (% hCD115) | ||
| hCD115 (WT) | NA | NA | -15.0 (100.0) |
| hCD115 I1A | 0.38 | neutral | -12.4 (82.7) |
| hCD115 V8G | 2.27 | destabilizing | -9.5 (63.3) |
| hCD115 A17E | -1.83 | stabilizing | -11.1 (74.0) |
| hCD115 K14E | -0.95 | stabilizing | Not done |
| mCD115 (WT) | NA | NA | Not done |
a Defined by the program with the following rule: stabilizing < -0.5 < neutral < 0.5 < destabilizing. bDocking scores with hCD115 from 4DKD co-crystal (used as reference) and models from computational mutagenesis. NA: Not Applicable