Table 2.
Comparing HoxB13 gene carriers to non-carriers according to select prostate cancer characteristics
| University of Michigan (UM) | Johns Hopkins (JH) | All | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GG | GA | GG | GA | GG | GA | ||||||||||
| Characteristic | N | % | N | % | p- value* |
N | percent | N | percent | p- value* |
N | percent | N | percent | p- value* |
| Total | 1274 | 15 | 6941 | 111 | 8215 | 126 | |||||||||
| Age at diagnosis / surgery | 0.43 | 0.0004 | 0.0003 | ||||||||||||
| ≤ 60 | 721 | 56.6 | 10 | 66.7 | 4371 | 63.0 | 88 | 79.3 | 5092 | 62.0 | 98 | 77.8 | |||
| > 60 | 553 | 43.4 | 5 | 33.3 | 2569 | 37.0 | 23 | 20.7 | 3122 | 38.0 | 28 | 22.2 | |||
| Family History | 0.28 | 0.01 | 0.006 | ||||||||||||
| No | 767 | 60.2 | 7 | 46.7 | 3948 | 56.9 | 49 | 44.1 | 4715 | 57.4 | 56 | 44.4 | |||
| Yes | 465 | 36.5 | 8 | 53.3 | 2447 | 35.3 | 50 | 45.0 | 2912 | 35.4 | 58 | 46.0 | |||
| Unknown | 42 | 3.3 | 0 | 0.0 | 546 | 7.9 | 12 | 10.8 | 588 | 7.2 | 12 | 9.5 | |||
| Pathologic Gleason Score | 0.56 | 0.95 | 0.95 | ||||||||||||
| < 7 | 324 | 25.4 | 2 | 13.3 | 4008 | 57.7 | 65 | 58.6 | 4332 | 52.7 | 67 | 53.2 | |||
| 7 (3+4) | 610 | 47.9 | 9 | 60.0 | 1767 | 25.5 | 29 | 26.1 | 2377 | 28.9 | 38 | 30.2 | |||
| ≥ 7 (4+3) | 298 | 23.4 | 4 | 26.7 | 1137 | 16.4 | 17 | 15.3 | 1435 | 17.5 | 21 | 16.7 | |||
| Unknown | 42 | 3.3 | 0 | 0.0 | 29 | 0.4 | 0 | 0.0 | 71 | 0.9 | 0 | 0.0 | |||
| Pathologic Tumor Stage | 1.0 | 0.51 | 0.52 | ||||||||||||
| ≤ T2 /N0 | 1051 | 82.5 | 13 | 86.7 | 4870 | 70.2 | 80 | 72.1 | 5921 | 72.1 | 93 | 73.8 | |||
| ≥T3 or any T/ N1 | 218 | 17.1 | 2 | 13.3 | 2040 | 29.4 | 29 | 26.1 | 2258 | 27.5 | 31 | 24.6 | |||
| Unknown | 5 | 0.4 | 0 | 0.0 | 31 | 0.4 | 2 | 1.8 | 36 | 0.4 | 2 | 1.6 | |||
*
Chi-square test or Fisher’s exact test for comparisons with small cells (excludes missing data).