Table 1.
Effect of ovariectomy and tempol on body weight and mesenteric arteriole (MRA) structure and p22phox expression
| Variable | Sham | ovx | Sham+Tempol | OVX + tempol | By ANOVA, effect of: |
||
|---|---|---|---|---|---|---|---|
| OVX | Tempol | Interaction | |||||
| Body weight (g) | 251±11 | 287±9 | 219±5 | 246±6 | P<0.001 | P<0.001 | NS |
| MRA media area (M; μm2) | 48±5 | 91±7 | 51±5 | 48±6 | P<0.01 | P<0.01 | P<0.01 |
| MRA lumen area (L; μm2) | 187±12 | 170±6 | 178±14 | 193±5 | NS | NS | NS |
| MRA M/L ratio (cross section area, μm2/μm2) | 1.54±0.29 | 3.43±0.38* | 1.53±0.24 | 1.63±0.19 | P<0.05 | P<0.05 | P<0.05 |
| MRA p22phox expression (relative to β- actin) | 0.18±0.04 | 0.89±0.05** | 0.28±0.11 | 0.26±0.14 | P<0.01 | P<0.05 | P<0.001 |
Mean ± SEM value (n=6 per group). Compared to SHAM:
*
P<0.05.
**
P<0.01