Table 1.

Sample Characteristics

	No ARV N = 10	Ritonavir N = 10	Efavirenz N = 10	Atazanavir N = 10
Age (yrs)	38.1 (4.2)#	43.4 (2.5)	44.9 (4.0)	33.8 (4.4)
Weight (kg)	75.1 (4.9)	79.7 (6.1)	76.6 (5.5)	87.4 (5.9)
Female	6 [60%]	3 [30%]	4 [40%]	3 [30%]
Race:
African-American	2 [20%]	3 [30%]	2 [20%]	3 [30%]
Caucasian	8 [80%]	7 [70%]	8 [80%]	3 [30%]
Other	0 [0%]	0 [0%]	0 [0%]	4 [40%]
Nicotine Use (packs/day)	0.0 (0.0)	0.1 (0.1)	0.1 (0.1)	0.0 (0.0)
AST (U/L)
Normal Range: 10–41 U/L
Baseline	25.1 (2.1)	28.9 (2.4)	27.3 (1.8)	24.1 (1.8)
ARV Alone		25.1 (0.8)	32.9 (7.3)	21.7 (1.7)
DIS 250 mg	27.0 (2.4)	22.9 (0.9)	35.0 (8.7)	29.1 (6.8)
ALT (U/L)
Normal Range: 7–35 U/L
Baseline	23.3 (2.9)	25.4 (2.7)	23.9 (2.5)	21.9 (4.1)
ARV Alone		20.4 (2.1)	23.6 (3.0)	19.9 (2.4)
DIS 250 mg	24.4 (3.6)	20.2 (1.8)	37.2 (10.1)	26.8 (5.2)
ALK Phosphate (U/L)
Normal Range: 42–98 U/L
Baseline	73.5 (6.2)	71.8 (4.3)	71.9 (4.3)	85.1 (5.3)
ARV Alone		65.8 (4.5)	62.5 (6.3)	82.2 (5.3)
DIS 250 mg	76.3 (7.1)	67.5 (4.1)	80.1 (5.0)	86.6 (5.2)
Total Bilirubin (mg/dL)
Normal Range: 0.1–1.2 mg/dL
Baseline	0.6 (0.1)	0.7 (0.1)	0.7 (0.1)	0.6 (0.1)
ARV Alone		0.5 (0.0)	0.4 (0.0)	2.3 (0.4)*
DIS 250 mg	0.6 (0.1)	0.4 (0.0)	0.4 (0.0)	2.0 (0.5)*
Total Protein (g/dL)
Normal Range: 6.4–8.3 g/dL
Baseline	7.4 (0.2)	7.1 (0.1)	7.2 (0.1)	7.4 (0.1)
ARV Alone		6.6 (0.1)	6.8 (0.1)	6.9 (0.1)
DIS 250 mg	7.1 (0.1)	6.6 (0.1)	7.0 (0.2)	7.1 (0.1)
ECG QTc (ms)
Baseline	420.4 (5.4)	409.0 (4.7)	415.1 (4.8)	404.5 (5.0)
ARV Alone		410.6 (5.6)	415.3 (5.6)	384.9 (6.8)
DIS 62.5 mg	421.8 (3.9)	409.6 (5.6)	407.0 (8.8)	383.8 (5.9)
DIS 250 mg	420.8 (6.5)	403.7 (6.3)	403.1 (6.0)	380.4 (7.1)

^#Mean (SE), [ ] percent of sample affected

^*p ≤0.01

Other Race includes Hispanic, Native American, Pacific Islander and Multi-Racial individuals