Table 1.

Baseline Parameters

	Placebo (n=12)		DPP4 inhibition (n=11)
Variable	Vehicle	ACE inhibition	Vehicle	ACE inhibition
DPP4 Activity (U/L)	24.3±7.0		4.8±3.0*
DPP4 Antigen (ng/mL)	571.5±187.0		561.7±116.4
ACE Act (U/L)	37.4±7.6	8.1±3.3†	37.0±7.2	11.0±8.6‡
MAP (mm Hg)	86.4±6.2	84.2± 5.2	85.1±5.4	82.8±4.1
Heart rate (bpm)	61.5±9.7	62.4±8.3	62.9±10.0	65.0±10.0
FVR (mmHg/ml/min/100mL)	37.7±12.4	30.4± 10.0†	30.6±8.5†	27.1±7.3
FBF (ml/min/100mL)	2.6±0.8	3.2±1.1†	3.1±0.9†	3.4±1.0

Results are presented as mean± standard deviation

MAP, mean arterial pressure; DPP4, dipeptidyl peptidase-4; ACE, angiotensin-converting enzyme; bpm, beats per minute; FVR, forearm vascular resistance; FBF, forearm blood flow

^*p<0.05 versus placebo,

^†p<0.05 versus placebo/vehicle,

^‡p<0.05 versus DPP4 inhibition/vehicle