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. Author manuscript; available in PMC: 2014 Sep 24.
Published in final edited form as: Nat Commun. 2014 Mar 24;5:3483. doi: 10.1038/ncomms4483

Figure 2. Several UPRmt inducing RNAi clones extend lifespan.

Figure 2

(a) N2 fed EV(RNAi) (mean 15.8 ± .2 days, n = 284), N2 fed Y24D9A.8(RNAi) (mean 19.8 ± .2 days, n = 316, p < 0.0001). (b) N2 fed EV(RNAi) (mean 15.0 ± .1 days, n = 320), N2 fed letm-1(RNAi) (mean 18.1 ± .2 days, n = 318, p < 0.0001). (c) N2 fed EV(RNAi) (mean 14.3 ± .1 days, n = 267), N2 fed Y110A7A.19(RNAi) (mean 16.8 ± .1 days, n = 360, p < 0.0001). (d) N2 fed EV(RNAi) (mean 14.6 ± .1 days, n = 266), N2 fed F02A9.4(RNAi) (mean 16.6 ± .2 days, n = 302, p < 0.0001). (e) N2 fed EV(RNAi) (mean 17.4 ± .2 days, n = 264), N2 fed wah-1(RNAi) (mean 19.6 ± .2 days, n = 301, p < 0.0001). (f) N2 fed EV(RNAi) (mean 16.5 ± .2 days, n = 279), N2 fed Y54G9A.7(RNAi) (mean 18.5 ± .2 days, n = 266, p < 0.0001). (g) N2 fed EV(RNAi) (mean 15.7 ± .1 days, n = 293), N2 fed lpd-9(RNAi) (mean 17.3 ± .2 days, n = 226, p < 0.0001). (h) The hsp-6p::gfp reporter is induced by knockdown of longevity conferring RNAi clones. hsp-6p::gfp worms were placed onto RNAi bacteria from egg and GFP measurements were taken three days later. Scale bar, 0.3 mm. Lifespans experiments in this figure were performed at 25°C. N=3 independent experiments, with pooled data shown. Lifespans are indicated as mean +/− SEM and p-values were calculated using Wilcoxon rank-sum test. Data by individual experiment and statistical analysis provided in Supplementary Materials (Supplementary Data 1).