Table 1.
Effects of 19 UPRmt regulators on lifespan.
| Effect on Mean Lifespan | ||||
|---|---|---|---|---|
| Condition | Gene Function/Domain | (% EV) | p | n |
| Y24D9A.8(RNAi) | Transaldolase | 25.6 | 7.9E-42 | 316/284 |
| letm-1(RNAi) | Ca2+-binding transmembrane protein, LETM1/MRS7 | 21.1 | 2.7E-39 | 318/320 |
| Y110A7A.19(RNAi) | Pentatricopeptide repeat-containing protein 3 | 17.9 | 1.5E-34 | 360/267 |
| F02A9.4(RNAi) | Methylcrotonoyl-Coenzyme A carboxylase 2, beta subunit | 13.3 | 1.5E-16 | 302/266 |
| wah-1(RNAi) | Programmed cell death 8, AIF homologue | 12.7 | 7.1E-13 | 301/264 |
| Y54G9A.7(RNAi) | Unknown | 12.0 | 3.6E-13 | 266/279 |
| lpd-9(RNAi) | Unknown | 10.2 | 1.1E-11 | 226/293 |
| W02F12.5(RNAi) | Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit) | 8.2 | 7.0E-04 | 237/242 |
| Y22D7AL.10(RNAi) | HSP10 homologue | 5.5 | 4.8E-05 | 309/335 |
| F15D3.6(RNAi) | UPS2/UPS3 homologue | 4.8 | 1.6E-03 | 371/323 |
| C04C3.3(RNAi) | Pyruvate dehydrogenase E1, beta subunit | −0.1 | 5.6E-01 | 302/279 |
| ech-6(RNAi) | Enoyl-CoA hydratase | −1.1 | 9.4E-01 | 306/296 |
| hsp-60(RNAi) | HSP60 homologue | −4.0 | 8.6E-02 | 187/282 |
| F15D3.7(RNAi) | Translocase of inner mitochondrial membrane complex, subunit TIM23 | −7.4 | 1.3E-07 | 217/260 |
| E04A4.5(RNAi) | Translocase of inner mitochondrial membrane complex, subunit TIM17 | −7.7 | 4.4E-07 | 199/260 |
| F45G2.8(RNAi) | Translocase of inner mitochondrial membrane complex, subunit TIM16 | −7.9 | 8.8E-05 | 291/279 |
| dnj-21(RNAi) | Translocase of inner mitochondrial membrane complex, subunit TIM14 | −10.5 | 4.5E-14 | 270/293 |
| T09B4.9(RNAi) | Translocase of inner mitochondrial membrane complex, subunit TIM44 | −11.1 | 2.4E-14 | 289/260 |
| tomm-22(RNAi) | Translocase of outer mitochondrial membrane complex, subunit TOM22 | −14.5 | 9.9E-28 | 327/335 |
RNAi knockdown of the shown genes significantly induced expression of the hsp-6p::gfp reporter. The effect on mean lifespan from each RNAi clone is shown relative to empty vector (EV) treated animals. p-values are shown for a Wilcoxon Rank-Sum comparison to EV control. n is number of animals for a certain RNAi treatment compared to EV control.